Ron Roenicke said this has been the toughest year in his three years since becoming Brewers' manager.
His team came into the season expected to contend in the National League Central, but has a record of 41-58 in a season hampered by injures. Then, the Brewers found out on Monday that their slugger Ryan Braun will be suspended for the remainder of the season.
"This year's been a rough year," Roenicke said. "There's been a lot that's happened. I'm pretty comfortable in knowing that these guys can move on.
"They moved on last year when we had the big injuries that really hurt, and then we moved on this year when we've had the injuries that really hurt. They're pretty good and focused in on what we need to be to try to win games."
Things should return to normal on Wednesday, when the Brewers take on the Padres at Miller Park for the third of a four-game series.
One bright spot for the Brewers has been their free-agent pickup, right-hander Kyle Lohse. In his last 10 starts, Lohse is 5-1 with a 2.63 ERA.
The Padres have taken the first two games of this series, including a 6-2 win on Tuesday -- the first time they have won consecutive games since June 20-21.
Sean O'Sullivan will start in place of the injured Jason Marquis, who will have reconstructive elbow surgery that will force him to miss the rest of the season.
O'Sullivan is a San Diego native who admitted to being a little nervous in his last start -- July 12 against the Giants, in what was his first career start for the Padres. He grew up rooting for the Padres and then got to pitch in front of a sold-out crowd of 42,361 at Petco Park.
"There were some extra nerves and excitement going into that one, pitching for my hometown team," O'Sullivan said. "It was almost like it was my [big league] debut all over again."
He only allowed two runs, but needed 102 pitches to get through five innings.
"My goal this time is to go farther into the game, that's something I take pride in," O'Sullivan said. "And I want to attack the zone. [The Giants] were spoiling good pitches, turning them into six-, seven-pitch at-bats. I'm looking for early contact and turning it over to our defense."
Padres: Street tweaks his slider
Closer Huston Street hasn't allowed a run in his last six outings, thanks to a new grip on his slider.
Pitching coach Darren Balsley suggested the adjustment, intended to produce a tighter spin and sharper break.
Street struggled early in the season, allowing 10 home runs in his first 26 1/3 innings, although he has only blown one save in 18 chances.
"The last three weeks have started to feel more right for me," Street said.
Brewers: Rodriguez traded to the Orioles
The Brewers traded reliever Francisco Rodriguez to Baltimore for third baseman Nick Delmonico on Tuesday.
The 21-year old Delmonico was drafted in the sixth round by Baltimore in the 2011 First-Year Player Draft, and was the fifth-ranked prospect in the Orioles' system. He hit .244 with 13 home runs and 30 RBIs in 60 games with Class A this season.
Rodriquez had converted all 10 of his save opportunities for the Brewers this season with a 1.09 ERA.
• Brewers outfielder Khris Davis hit his first career home run in the eighth inning on Tuesday. Davis will be one of the players that will help replace Braun in the outfield. His homer ended a streak of 11 consecutive scoreless innings by the Padres' bullpen.
• Will Venable went 3-for-5 on Tuesday to improve his career average at Miller Park to .397 (25-for-63), the third best all-time at that ballpark.
Jamal Collier is an associate reporter for MLB.com. This story was not subject to the approval of Major League Baseball or its clubs.